Chemical Carcinogenesis in the Hamster Cheek Pouch

Autor:	I.S. Levij, D. Rubin
Rok vydání:	1975
Předmět:	Chemistry Cell Cell Biology General Medicine medicine.disease_cause Pathology and Forensic Medicine medicine.anatomical_structure Biochemistry Cheek pouch medicine Alkaline phosphatase Inducer Carcinogenesis Molecular Biology
Zdroj:	Pathobiology. 43:26-30
ISSN:	1423-0291 1015-2008
DOI:	10.1159/000162791
Popis:	Squamous cell carcinomas were induced in the hamster cheek pouch with 9,10-dimethyl-1, 2-benzanthracene. The process of carcinogenesis was inhibited by phenylphosphate, an inducer of alkaline phosphatase. Orthophosphate and l-phenylalanine, which inhibit alkaline phosphatase, had a promoting effect on tumor formation. The results are in accordance with those of previous studies on the effect of inducers of alkaline phosphatase on chemical carcinogenesis. The effect of the studied substances on carcinogenesis was apparently unrelated to the presence of phenyl or phosphate groups or of steroid rings. The tumor inhibition or promotion seemed to be related to the potential of the tested substances to induce or inhibit alkaline phosphatase activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::879daa666938d4e1c6a95ea2504d3d4a https://doi.org/10.1159/000162791 Zobrazit plný text záznamu