Oral HIV-1 recovery in the presence of periodontal disease
| Autor: | MN Qureshi, W Zhang, J Kaim, CE Barr, Z Qiu |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Drug
Saliva business.industry Potential risk Viral culture media_common.quotation_subject Human immunodeficiency virus (HIV) virus diseases medicine.disease_cause Peripheral blood mononuclear cell Otorhinolaryngology Periodontal disease Immunology Medicine business Serostatus General Dentistry media_common |
| Zdroj: | Oral Diseases. 2:198-201 |
| ISSN: | 1354-523X |
| DOI: | 10.1111/j.1601-0825.1996.tb00224.x |
| Popis: | OBJECTIVE: To determine whether a significant association occurs between the presence of various periodontal diseases and recoverable infectious HIV-1 in the saliva of injecting drug users. DESIGN: Five hundred and fifty-one injecting drug users were recruited from various programs associated with the Beth Israel Medical Center. Examiners were ‘blinded’ to the subject's HIV-1 serostatus. A socio-economic and risk factors’ survey was conducted and a complete oral examination, including periodontal disease indices was performed. Whole saliva and blood were collected for virus culture. MAIN OUTCOME MEASURES: Recovery of infectious HIV-1 in saliva related to presence of periodontal diseases. RESULTS: Those HIV-1 seropositive subjects with periodontal diseases did not differ from those HIV-1 seropositive subjects without periodontal disease in mean age and immune status. Less than 1% of the HIV-1 seropositive subjects had cultivable HIV-1 in their saliva while it was present in 78% of PBMCs and 35% of the sera. There was no significant association between infectious HIV-1 in saliva, serum, or PBMCs and any of the various periodontal diseases. CONCLUSIONS: The presence of periodontal disease in HIV-1 seropositive injecting drug users does not appear to be a potential risk factor for infectious HIV-1 in saliva, probably due to the various anti-viral components of saliva. |
| Databáze: | OpenAIRE |
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