| Autor: |
Anthony Watson, Christine P. J. Caygill, Santanu Bhattacharjee |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Posters. |
| DOI: |
10.1136/gutjnl-2019-bsgabstracts.256 |
| Popis: |
Introduction To investigate association between the type of occupation and progression of Barrett’s oesophagus (BO) to high grade dysplasia (HGD) and oesophageal adenocarcinoma (OAC). Methods 2971 patients diagnosed with BO and enrolled with the United Kingdom Barrett’s oesophagus Registry (UKBOR) formed the cohort for the study. Medical records were examined and patients’ occupation were recorded. Patients without an occupation were excluded as were housewives and those unemployed. Histology from endoscopic surveillance of BO patients was sought with HGD or OAC used as the end point. Occupations were categorised into groups with similar job descriptions or work environments as shown in table 1. The number of Barrett’s patients and those developing HGD and OAC in each occupation category was documented and the proportion of the cohort developing HGD and OAC calculated for each occupation category. The p-value for each group was calculated using Fisher’s exact test. Results 1525 patients with BO and 241 patients who developed OAC and HGD had their occupation recorded and these were used for analysis (table 1). The occupation types with the largest proportion of OAC and HGD in the cohort were metalwork and factory workers (16.8%, p-value 0.08), warehouse and storage workers (26.9%, p-value 0.07) and chemical and processing workers (19.1%, p-value 0.09). Office & sedentary workers had a significantly lower proportion of to progression OAC and HGD (8.9%, p-value 0.0008). Conclusion BO patients with sedentary occupations were significantly less likely to progress to HGD or OAC than those in more active occupations. Fisher’s exact test was used to calculate the significance of each occupation group in determining its association with oesophageal adenocarcinoma. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
