Cholinergic regulation of transcription processes in the liver
| Autor: | Dolgo-Saburov Vb, Podosinovikova Np, Matveev Vi |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
medicine.medical_specialty
Carbachol Stimulation General Medicine Biology General Biochemistry Genetics and Molecular Biology medicine.anatomical_structure Endocrinology Transcription (biology) Hepatocyte Internal medicine Transcription preinitiation complex medicine Cholinergic Acetylcholine medicine.drug Acetylcholine receptor |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 88:997-1000 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf00799264 |
| Popis: | Intramuscular injection of acetylcholine, carbachol, or chlorosil into rats in doses of 20, 1, and 2 mg/kg respectively caused an increase in the rate of RNA synthesis in liver tissue after 6 h. In a dose of 0.025 mg/kg chlorosil did not affect this process but partially blocked the stimulation of transcription by carbachol. In a system of isolated hepatocyte nuclei carbachol and chlorosil did not change the rate of RNA synthesis. It is suggested that the effect of cholinergic ligands on the transcription complex is indirect and is due to their interaction with a cholinergic receptor or a site structurally connected with it in the hepatocyte plasma membrane. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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