Anti-oxidant, anti-inflammatory and anti-cancer activities of avocado (Persea americana) fruit and seed extract
| Autor: | Manal E.A. ELhalwagy, Maha I. Alkhalaf, Eman A. Ibrahim, Wafa S. Alansari |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Persea
Multidisciplinary ABTS Antioxidant biology Traditional medicine medicine.drug_class DPPH medicine.medical_treatment food and beverages 02 engineering and technology 010501 environmental sciences 021001 nanoscience & nanotechnology biology.organism_classification 01 natural sciences Anti-inflammatory Bulb chemistry.chemical_compound Oleic acid chemistry medicine 0210 nano-technology Unsaturated fatty acid 0105 earth and related environmental sciences |
| Zdroj: | Journal of King Saud University - Science. 31:1358-1362 |
| ISSN: | 1018-3647 |
| DOI: | 10.1016/j.jksus.2018.10.010 |
| Popis: | Avocado (Persea americana) seeds represent under-utilised resources and waste issues in avocado processing. This study was produced to compare the lipid contents of the avocado bulb and seed. The study also evaluated the anti-oxidant, anti-inflammatory and anti-cancer potentiality of each extract. Oleic acid was the predominant unsaturated fatty acid in a chloroform/methanol extract of P. americana fruit and seed. The seed extract was richer with sterol compounds than the fruit extract. The extracts exhibited anti-inflammatory and anti-cancer activities against cell line of colon cancer (HCT116) and cell line of liver cancer (HePG2) in a dose-dependent manner. It also exhibited powerful scavenging of free radical by using- DPPH and ABTS. IC50 of seed extract against the aforementioned cancer cell lines was more or less near the values of a reference drug (sorafinib). In conclusion, P. americana seed extract has more powerful effects than avocado bulb extract. The seeds should not be neglected. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|