Synthesis of phenanthroline-based ligand and its UV activable tetracarbonyl photoCORMs based on chromium, molybdenum, and tungsten as cytotoxic and antimicrobial agents
| Autor: | Richard C.S. Wong, Wee Li Mah, Shiaw Xian Lee, Kae Shin Sim, Yuen Lin Cheow, Chun Hoe Tan, Kong Wai Tan, Chew Hee Ng |
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| Rok vydání: | 2021 |
| Předmět: |
Tungsten hexacarbonyl
Ligand Phenanthroline Organic Chemistry chemistry.chemical_element Crystal structure Tungsten medicine.disease_cause Biochemistry Inorganic Chemistry Chromium chemistry.chemical_compound chemistry Molybdenum Materials Chemistry medicine Physical and Theoretical Chemistry Ultraviolet Nuclear chemistry |
| Zdroj: | Journal of Organometallic Chemistry. :122103 |
| ISSN: | 0022-328X |
| DOI: | 10.1016/j.jorganchem.2021.122103 |
| Popis: | A phenanthroline-based ligand L1 ((((1,10-phenanthrolin-5-yl)imino)methyl)-6-methoxyphenol) was synthesized and reacted with chromium, molybdenum, and tungsten hexacarbonyl to form ultraviolet (UV) activable photoCORMs C1, M1, and T1, respectively. All compounds were characterized via IR, 1H-NMR, 13C-NMR, and CHN elemental analyses, and the X-ray crystal structures of L1 and M1 were determined. The half-life of the photoCORMs decreased with an increasing concentration and the rate of CO release increased in the order of T1 |
| Databáze: | OpenAIRE |
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