Differential uptake of and sensitivity to diphenhydramine in embryonic and larval zebrafish
| Autor: | Samuel P. Haddad, C. Kevin Chambliss, Bryan W. Brooks, Lauren A. Kristofco |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
animal structures Toxicodynamics biology Chemistry Health Toxicology and Mutagenesis fungi Diphenhydramine Embryo 010501 environmental sciences biology.organism_classification 01 natural sciences Embryonic stem cell Andrology 03 medical and health sciences 030104 developmental biology embryonic structures Toxicity medicine Zebrafish larvae Environmental Chemistry Toxicokinetics Zebrafish 0105 earth and related environmental sciences medicine.drug |
| Zdroj: | Environmental Toxicology and Chemistry. 37:1175-1181 |
| ISSN: | 0730-7268 |
| Popis: | The zebrafish fish embryo toxicity (FET) test is increasingly employed for alternative toxicity studies, yet our previous research identified increased sensitivity of zebrafish slightly older than embryos employed in FET methods (0-4 d postfertilization [dpf]). We identified rapid steady-state accumulation of diphenhydramine across zebrafish embryo and larval stages. However, significantly (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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