Heterogeneity of tibial plateau cartilage in response to a physiological compressive strain rate

Autor:	Scott G. McLean, Kelly E. Newman, Ellen M. Arruda, Jessica M. Deneweth, Stephen M. Sylvia
Rok vydání:	2012
Předmět:	Cartilage Biomechanics Osteoarthritis Anatomy Meniscus (anatomy) Biology Strain rate musculoskeletal system Plateau (mathematics) medicine.disease medicine.anatomical_structure Tangent modulus medicine Orthopedics and Sports Medicine Cadaveric spasm
Zdroj:	Journal of Orthopaedic Research. 31:370-375
ISSN:	0736-0266
DOI:	10.1002/jor.22226
Popis:	Knowledge of the extent to which tibial plateau cartilage displays non-uniform mechanical topography under physiologically relevant loading conditions is critical to evaluating the role of biomechanics in knee osteoarthritis. Cartilage explants from 21 tibial plateau sites of eight non-osteoarthritic female cadaveric knees (age: 41-54; BMI: 14-20) were tested in unconfined compression at 100% strain/s. The elastic tangent modulus at 10% strain (E(10%) ) was calculated for each site and averaged over four geographic regions: not covered by meniscus (I); covered by meniscus-anterior (II); covered by meniscus-exterior (III); and covered by meniscus-posterior (IV). A repeated-measures mixed model analysis of variance was used to test for effects of plateau, region, and their interaction on E(10%) . Effect sizes were calculated for each region pair. E(10%) was significantly different (p
Databáze:	OpenAIRE
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