A 6-year review of new psychoactive substances at the Centre antipoison Grand-Ouest d’Angers: Clinical and biological data
| Autor: | Chloé Bruneau, Séverine Férec, Alain Turcant, Florence Jegou, Gaël Le Roux, Bénédicte Lelièvre, David Boels, C. Gegu, M. Deguigne, Chadi Abbara, Isabelle Leborgne |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class business.industry Health Toxicology and Mutagenesis 010401 analytical chemistry Acute intoxication Clinical state Context (language use) Recreational use Toxicology 01 natural sciences 0104 chemical sciences Designer drug 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry Methiopropamine Acute exposure medicine 030216 legal & forensic medicine business Psychiatry |
| Zdroj: | Toxicologie Analytique et Clinique. 29:18-33 |
| ISSN: | 2352-0078 |
| DOI: | 10.1016/j.toxac.2016.12.001 |
| Popis: | Summary For the last 10 years, recreational use of new psychoactive substances (NPS) with hallucinogenic properties was more and more described either in a context of consumption during a rave-party or at home alone or in small group. A review of 62 cases (56 M, 6 F, 16–46 y) registered from 2011 to 2016 at the French Grand Ouest centre antipoison of Angers is presented. Some of them (n = 15) presented a severe clinical state (poison severity score, PSS = 3) and only one was a fatal intoxication (PSS = 4). Treatment of acute intoxication was mainly based on supportive care with a quick recovery in less than 48 h. A high number of these cases were documented by plasma (pl) and/or urine analyses using LC-UV, GC-MS and LC-MS2. Several powders or other forms bought on the web market by the patients were also analysed. Six amphetamines derivates were detected such as methiopropamine (pl: 50 – 430 μg/L, n = 6) or 5 others (6-APB, 6-APDB, 5-EAPB, 5-MAPB, 2-FA each once). Four 2,5-dimethoxy-derivates of phenylethylamines (2Cs) or of amphetamines (DOs) were detected as 2C-P (pl |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|