Autoimmune comorbidity in achalasia patients
| Autor: | Samuel Torres-Landa, Elizabeth Olivares-Martínez, Diego F. Hernández-Ramírez, Axel A. Hernández-Ávila, Bárbara Ramos-Ávalos, Axel Palacios, Fernanda Romero-Hernández, Gabriela Hernández-Molina, Edgar Alejandro-Medrano, Janette Furuzawa-Carballeda, Miguel A. Valdovinos, Athenea Flores-Najera, Blanca A. Blancas Breña, Enrique Coss-Adame, Gonzalo Torres-Villalobos, Daniel Azamar-Llamas, Carlos A. Núñez-Álvarez |
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| Rok vydání: | 2017 |
| Předmět: |
Autoimmune disease
medicine.medical_specialty Hepatology business.industry Gastroenterology Autoantibody Achalasia Disease medicine.disease Systemic inflammation Comorbidity digestive system diseases 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine otorhinolaryngologic diseases GERD medicine 030211 gastroenterology & hepatology Family history medicine.symptom business |
| Zdroj: | Journal of Gastroenterology and Hepatology. 33:203-208 |
| ISSN: | 0815-9319 |
| DOI: | 10.1111/jgh.13839 |
| Popis: | Background Idiopathic achalasia is a rare esophageal motor disorder. The disease state manifests local and systemic inflammation, and it appears that an autoimmune component and specific autoantibodies participate in the pathogenesis. Aim To determine the prevalence of autoimmune and chronic inflammatory diseases in patients with achalasia and compare the results with those from patients with gastroesophageal reflux disease (GERD). Methods It was a cross-sectional and included 114 patients with idiopathic achalasia and 114 age-and sex-matched control patients with GERD. Data on the presence of autoimmune and inflammatory diseases, the time of presentation and any family history of autoimmune disease were obtained from the hospital's medical records. Results Seventy three (64%) were females (mean age: 42.3±15.5; median disease duration: 12mo). We identified the presence of autoimmune disease in 19 patients with achalasia (16.7%), hypothyroidism was the main diagnosis, and it was present in 52.6% of patients compared with 4.2% in controls. Thirteen of the 19 achalasia patients (68.4%) with autoimmune disease had history of familial autoimmunity. We identified 11 achalasia (9.6%) and 5 GERD patients (4.16%) with an inflammatory condition. Compared to the GERD, the achalasia group was 3.8-times more likely to have an autoimmune disease (95%CI: 1.47-9.83), 3.0-times more likely to have thyroidopathies (95%CI: 1.00-9.03) and 3.02-times more likely to suffer from any chronic inflammatory disease (95%CI:1.65-6.20). Conclusions The non-negligible number of patients with autoimmune diseases identified among the patients with idiopathic achalasia supports the hypothesis that achalasia has an autoimmune component. |
| Databáze: | OpenAIRE |
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