ANIMAL MODELS AND THE EMERGENCE OF GEROSCIENCE

Autor: Steven Austad
Rok vydání: 2022
Předmět:
Zdroj: Innovation in Aging. 6:340-340
ISSN: 2399-5300
DOI: 10.1093/geroni/igac059.1345
Popis: Aging, meaning the generalized deterioration in physical and mental function with time, influences nearly all living species. Moreover, many underlying biological mechanisms of aging appear to be conserved. At the same time, there appear to be great differences in the rate at which different species age. Research using both traditional and nontraditional animal species, employing both laboratory and field studies has offered important insights into the discovery of underlying causes of aging. Also, a variety of studies using well-established animal models of aging have now identified both repurposed medications and new compounds and other approaches that appear to slow biological aging with potential improvements in lifespan and healthspan. It is these findings, when framed in the context of the emergence of multiple chronic diseases with aging, that have led to the Geroscience Hypothesis.
Databáze: OpenAIRE