Reduction of Radiation-Induced Hair Loss by Topical Application of Radioprotectors

Autor:	Marvin Sodicoff, Albert A. Lamperti, Alan D. Conger, Leslie Delaney
Rok vydání:	1994
Předmět:	Pharmacology Ethanol Chemistry Stereochemistry Dimethyl sulfoxide medicine.medical_treatment Organic Chemistry Pharmaceutical Science Radiation induced medicine.disease Dosage form chemistry.chemical_compound Hair loss Pharmacokinetics Drug Discovery medicine Saline Cysteine
Zdroj:	Drug Development and Industrial Pharmacy. 20:1971-1989
ISSN:	1520-5762 0363-9045
DOI:	10.3109/03639049409049331
Popis:	Our transdermal permeation studies of radioprotectors in permeation-enhancing vehicles led us to hypothesize that radiation-induced hair loss could be reduced by topical application of radioprotectors. In the present study we used a hair regrowth assay in “plucked” mice to measure the radioprotective effectiveness of WR-1065, cysteine and TEMPOL when they were dissolved in a variety of vehicles, i.e., saline, dimethyl formamide (DMF), propylene glycol (PG), dimethyl sulfoxide (DMSO), ethanol. Protector effectiveness varied with radiation dose and vehicles. At 600 R, WR-1065 or cysteine, in any vehicle, reduced radiation-induced baldness scores; at 800 R, only WR-1065 in DMF and cysteine in saline, produced some protection. TEMPOL in ethanol produced protection at both the 600 and 800 R. Results suggest that suitably chosen topical application of protector/vehicle combinations can reduce radiation-induced hair loss.
Databáze:	OpenAIRE
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