Inhibitory Effects of Ticlopidine and Dilazep on Serum-Induced DNA Synthesis in Cultured Rat Renal Mesangial Cells

Autor:	Noriaki Ohnishi, Kazuki Nagasawa, Teruyoshi Yokoyama, Masako Nomiyama
Rok vydání:	1998
Předmět:	Drug DNA synthesis Chemistry media_common.quotation_subject Dilazep Glomerulonephritis Pharmacology Inhibitory postsynaptic potential medicine.disease Dipyridamole medicine Ticlopidine Fetal bovine serum media_common medicine.drug
Zdroj:	Japanese Journal of Hospital Pharmacy. 24:17-22
ISSN:	2185-9477 0389-9098
DOI:	10.5649/jjphcs1975.24.17
Popis:	The effect of two anti-platelet drugs, ticlopidine and dilazep, on the fetal bovine serum (FBS)-induced DNA synthesis of cultured rat renal mesangial cells was assessed by means of an [3H] thymidine incorporation assay. Each drug inhibited the 2% FBS-induced [3H] thymidine incorporation in a concentration-dependent manner, similar to the inhibition of dipyridamole. The [3H] thymidine incorporation was significantly suppressed by the treatment of more than 1 pM ticlopidine or dilazep. It was thus suggested that ticlopidine and dilazep, might prevent the progression of such glomerular diseases as proliferative glomerulonephritis, at least in part, by suppressing mesangial cell proliferation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8753ded114dd13d93f179c2e28ec5597 https://doi.org/10.5649/jjphcs1975.24.17 Zobrazit plný text záznamu