Retroperitoneal xanthogranuloma and xanthosarcoma (malignant fibrous xanthoma)

Autor:	Leonard B. Kahn
Rok vydání:	1973
Předmět:	Cancer Research Local excision Pathology medicine.medical_specialty business.industry Xanthoma medicine.disease eye diseases Oncology Pleomorphism (cytology) medicine Retroperitoneal xanthogranuloma business Histiocyte
Zdroj:	Cancer. 31:411-422
ISSN:	1097-0142 0008-543X
DOI:	10.1002/1097-0142(197302)31:2<411::aid-cncr2820310219>3.0.co;2-0
Popis:	A case of retroperitoneal xanthosarcoma (malignant fibrous xanthoma, malignant variant of xanthogranuloma) is described. In addition to the typical histologic features of retroperitoneal xanthogranuloma, this tumor showed obvious pleomorphism and mitotic activity of the proliferating histiocytes. The patient developed visceral metastases and died. The ultrastructural studies confirmed the presence of histiocytic-type cells. A review of cases diagnosed as retroperitoneal xanthogranuloma, including cases of malignant fibrous xanthoma, indicates an extremely poor prognosis for the histologically malignant variant. The usual histologic variant has an unpredictable behavior, some patients remaining well following local excision or even totally inadequate therapy while others have died following complete removal of the tumor.
Databáze:	OpenAIRE
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