Preliminary studies on the hydroalcoholic extract of the root ofCissampelos sympodialis Eichl in guinea-pig tracheal strips and bronchoalveolar leucocytes

Autor:	C. C. Araújo, M de Fátima Agra, Maria Bachelet, M. de F. F. Melo Diniz, G. Thomas, B. B. Vargaftig
Rok vydání:	1995
Předmět:	Pharmacology Agonist Cissampelos Carbachol biology medicine.drug_class Substance P biology.organism_classification Guinea pig chemistry.chemical_compound chemistry Immunology medicine Cyclic adenosine monophosphate Aminophylline Histamine medicine.drug
Zdroj:	Phytotherapy Research. 9:473-477
ISSN:	1099-1573 0951-418X
Popis:	The aqueous fraction of the ethanol extract of the root of Cissampelos sympodialis, reduced the spontaneous tone, and inhibited the contractions induced by submaximal concentrations of carbachol, histamine, prostaglandin F 2α and substance P, in guinea-pig tracheal preparations. The fraction was approximately equipotent to aminophylline and the IC 50 values of the above agents varied from 13.9 to 95.5 μg/mL, depending on the agonist used. In concentrations ranging from 1-100 μg/mL, the fraction also increased the intracellular levels of cyclic adenosine monophosphate in guinea-pig bronchoalveolar leucocytes. It is proposed that the combined effects on smooth muscles and on leucocytes indicate a pharmacological basis for the use of the plant in asthma.
Databáze:	OpenAIRE
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