One-pot approach: Tandem consecutive Ugi-4CR/ACM-type reaction towards the synthesis of functionalised quinoline-2(1H)-one scaffolds

Autor:	Chinpiao Chen, Chih-Yu Wu, Sivan Perumal Murugan, Gene-Hsian Lee
Rok vydání:	2021
Předmět:	Tandem 010405 organic chemistry Isocyanide Organic Chemistry Quinoline 010402 general chemistry Metathesis 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences Catalysis Acetic acid chemistry.chemical_compound chemistry Intramolecular force Drug Discovery
Zdroj:	Tetrahedron Letters. 67:152889
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2021.152889
Popis:	We report the synthesis of functionalised quinolin-2-(1H)-one analogues by a one-pot approach through a tandem consecutive Ugi-4CR/intramolecular alkyne-carbonyl metathesis (ACM) type reaction, in which Pd(OAc)2 is used as a catalyst in the presence of acetic acid. The first step is the preparation of an Ugi-4CR intermediate using simple precursors 2′-aminoacetophenone and cyclohexyl isocyanide with various propiolic acids and aldehydes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8744accb1b98200de26e3edc78c9e9bb https://doi.org/10.1016/j.tetlet.2021.152889 Zobrazit plný text záznamu Full Text from ScienceDirect