Cytotoxic effect of a polymer–copper(II) complex containing 2,2′-bipyridyl ligand on human lung cancer cells

Autor:	Vaiyapuri Subbarayan Periasamy, Mohammad Abdulkadher Akbarsha, Sankaralingam Arunachalam, C. Preethy Paul, R. Senthil Kumar, Anvarbatcha Riyasdeen
Rok vydání:	2010
Předmět:	Cisplatin Necrosis Chemistry Organic Chemistry Ligand (biochemistry) Molecular biology respiratory tract diseases Apoptosis Cancer cell medicine Cytotoxic T cell MTT assay General Pharmacology Toxicology and Pharmaceutics medicine.symptom Cytotoxicity medicine.drug
Zdroj:	Medicinal Chemistry Research. 20:726-731
ISSN:	1554-8120 1054-2523
DOI:	10.1007/s00044-010-9380-8
Popis:	The cytotoxic activity of the polymer–copper(II) complex, [Cu(bpy)2(BPEI)]Cl2·4H2O (bpy = 2,2′-bipyridine, BPEI = branched polyethyleneimine) on NCI-H460 human lung cancer cells was determined adopting MTT assay and specific staining techniques. Many of the cultured NCI-H460 cancer cells treated with this complex suffered loss of viability and death mostly through apoptosis and/or necrosis as evidenced by the changes in the nuclear morphology and cytoplasmic features.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::873f5d87edb05f47547d1e8c1c6b41f2 https://doi.org/10.1007/s00044-010-9380-8 Zobrazit plný text záznamu Full text from SpringerLink