Persistently raised aspartate aminotransferase (AST) due to macro-AST in a rheumatology clinic
| Autor: | Andrew Gough, Nuthar Jassam, Claire King, Ahai Luvai, Joanne Foo, Wycliffe Mbagaya, Sarah Mapplebeck |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Pathology Normal liver function Abdominal ultrasound business.industry Health Policy Biochemistry (medical) Clinical Biochemistry Public Health Environmental and Occupational Health virus diseases Medicine (miscellaneous) Elevated ast digestive system Gastroenterology digestive system diseases fluids and secretions Rheumatology clinic Internal medicine Liver enzyme polycyclic compounds medicine Widespread pain Abnormal Liver Function Test In patient business |
| Zdroj: | Diagnosis. 2:137-140 |
| ISSN: | 2194-802X 2194-8011 |
| DOI: | 10.1515/dx-2014-0065 |
| Popis: | Macrocomplexes between immunoglobins and aspartate aminotransferase (macro-AST) may result in persistently increased AST concentration. The presence of macro-AST in patients has been implicated in unnec-essary investigations of abnormal liver function tests. We report the case of a 44-year-old female who presented to the rheumatology clinic with a 12-months’ history of constant widespread pain affecting her limbs and was found to have an elevated AST concentration. Further information from her GP revealed a 14-years’ history of elevated AST with otherwise normal liver function. Pre-vious abdominal ultrasound and two liver biopsies car-ried out 2 years apart were normal. This prompted further analytical investigation by the biochemistry department which identified macro-AST as the cause. This case illus-trates that persistently raised isolated AST concentration with no other abnormal indices may warrant macroen-zyme analysis potentially avoiding unnecessary invasive investigations. Keywords: AST ver li ; enzymes; macrASTo- ; macroenzyme. |
| Databáze: | OpenAIRE |
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