Effects of Superovulation on Ovarian Δ5-3β-Hydroxysteroid Dehydrogenase Activity in Rats of Different Ages

Autor:	Helen Wendler Deane, Betty L. Rubin
Rok vydání:	1965
Předmět:	Diminution medicine.medical_specialty media_common.quotation_subject Ovary Luteal phase Biology Endocrinology medicine.anatomical_structure Internal medicine medicine Specific activity Hydroxysteroid dehydrogenase Ovulation Corpus luteum media_common Hormone
Zdroj:	Endocrinology. 76:382-389
ISSN:	1945-7170 0013-7227
Popis:	Administration of gonadotrophic hormones to rats, utilizing a procedure that produces superovulation, resulted, as expected, in increases in ovarian Δ5-3β-hydroxysteroid dehydrogenase activity. However, differences in the magnitude of the response were observed depending upon the ages of the rats used. The maximum degree of response was seen in immature rats (22–43 days of age when treatment was initiated). There is a distinct diminution of responsiveness in animals 3–4 months of age. Mature animals (over 5 months of age) responded, but to higher doses, and less consistently, than immature rats. Moreover, increases in enzymic activity generally paralleled increases in ovarian weight, while the specific activity of the enzyme remained, as a rule, unchanged. The magnitude of the increase appeared to parallel the increased volume of luteal tissue. (Endocrinology 76: 382, 1965)
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::873c75468ec4a3a35e472e0d04d14857 https://doi.org/10.1210/endo-76-3-382 Zobrazit plný text záznamu