Mechanism of Tolerance of Immature Kidney to Anoxia † 1805
| Autor: | Norman J. Siegel, Gunilla Thulin, Karen M. Gaudio |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Creatinine Kidney Pathology business.industry Cellular polarity Ischemia medicine.disease Cortex (botany) chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry In vivo Internal medicine medicine.artery Pediatrics Perinatology and Child Health Medicine Renal artery business Densitometry |
| Zdroj: | Pediatric Research. 43:308-308 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-199804001-01828 |
| Popis: | We have previously shown that immature tubules are resistant to anoxia compared to mature tubules. This tolerance is accompanied by an exuberant production of activated heat shock transcription factor. To further assess the role of the stress response, in vivo ischemia was produced in immature and mature rats. Immature rats (IR), age 10 days, and mature rats(MR), age 10 weeks, underwent 45 min of bilateral renal artery ischemia(BRAI); 24 hrs later, serum creatinine (Cr) was drawn and kidneys were prepared for histologic evaluation. Serum Cr (mg/dl) confirmed tolerance to ischemia (I): non-I: 0.60 ± 0.03 IR, 0.45 ± 0.05 MR, (P=NS), I: 0.66 ± 0.02 IR; 2.5 ± 0.57 MR (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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