L’évaluation gériatrique et les scores pronostiques chez le patient âgé atteint de cancer : une aide à la décision thérapeutique ?
| Autor: | Mathilde Gisselbrecht, Stéphane Herbaud, Pascaline Boudou-Rouquette, Laurent Zelek, Frédéric Pamoukdjian, Evelyne Liuu, Philippe Caillet, Elena Paillaud |
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| Rok vydání: | 2017 |
| Předmět: |
Polypharmacy
Cancer Research medicine.medical_specialty education.field_of_study business.industry Population Cancer Hematology General Medicine Perioperative Disease medicine.disease Clinical trial 03 medical and health sciences 0302 clinical medicine Oncology Geriatric oncology 030220 oncology & carcinogenesis Epidemiology medicine Radiology Nuclear Medicine and imaging 030212 general & internal medicine Intensive care medicine education business |
| Zdroj: | Bulletin du Cancer. 104:946-955 |
| ISSN: | 0007-4551 |
| DOI: | 10.1016/j.bulcan.2017.10.004 |
| Popis: | Cancer is a disease of the elderly as demonstrated by the epidemiological evolution of Western countries. Indeed, two third of cancers newly diagnosed occur over 65 years. However, older cancer patients have been often excluded from clinical trials in oncology and the extrapolation of cancer treatments in this population remains difficult in practice. Scientific societies recommend that a comprehensive geriatric assessment (CGA) be performed in patients aged 70 and over and selected using screening tools for frailty such as the G8 index. The CGA allows to detect aging-related vulnerabilities in various domains (comorbidities, polypharmacy, autonomy, nutrition, mobility, cognition, mood, social) and associated with adverse outcomes during cancer treatment (reduced overall survival, perioperative complications, toxicity-related chemotherapy). The CGA is allow to elaborate a personalized treatment plan in geriatric oncology. However, to date, no algorithms based on CGA is validated to guide therapeutic decision in geriatric oncology. The collaboration between geriatrician and oncologist remains essential to elaborate an appropriate therapeutic strategy and limit the situations of over- and under-treatment. This article presents the set of tools and scores used in geriatric oncology to guide the therapeutic decision. |
| Databáze: | OpenAIRE |
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