Synthesis of new physiologically active (2-oxoimidazolidin-5-yl)indoles

Autor:	M. G. Akimov, L. A. Sviridova, Maria S. Dudina, Konstantin A. Kochetkov, Polina S. Protopopova, Elizaveta K. Melnikova
Rok vydání:	2020
Předmět:	Indole test Low toxicity 010405 organic chemistry Chemistry chemistry.chemical_element General Chemistry 010402 general chemistry Boron 01 natural sciences Medicinal chemistry 0104 chemical sciences
Zdroj:	Mendeleev Communications. 30:347-349
ISSN:	0959-9436
Popis:	Boron trifluoride-catalyzed amidoalkylation of indole derivatives with 5-hydroxy-1-phenylimidozolidin-2-one affords new biheterocycles with a direct C–C bond. Among them, 3- or 2-(2-oxoimidazolidin-5-yl)indoles manifest antiinflammatory activity with relatively low toxicity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8734970b3744ae5063e4137bb0efd5f9 https://doi.org/10.1016/j.mencom.2020.05.029 Zobrazit plný text záznamu Full Text from ScienceDirect