Current status of clinical testing for human papillomavirus in oropharyngeal squamous cell carcinoma
| Autor: | Kelly Y. Kim, Zhong Chen, James S. Lewis |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty business.industry Head and neck cancer Molecular diagnostics medicine.disease 3. Good health Pathology and Forensic Medicine Test (assessment) 03 medical and health sciences Hpv testing 030104 developmental biology 0302 clinical medicine Treatment dose 030220 oncology & carcinogenesis Internal medicine Medicine Standard test Oropharyngeal squamous cell carcinoma Human papillomavirus business |
| Zdroj: | The Journal of Pathology: Clinical Research. 4:213-226 |
| ISSN: | 2056-4538 |
| DOI: | 10.1002/cjp2.111 |
| Popis: | While a variety of human papillomavirus (HPV) tests and surrogate markers are available, currently there is no consensus on the best detection method(s) that should be used to identify HPV-related oropharyngeal squamous cell carcinomas and serve as a standard test (or tests) for routine diagnostic use. As we begin to consider using the results of HPV testing for clinical purposes beyond simple prognostication, such as making decisions on treatment dose or duration or for targeted therapies that may be highly dependent on viral-mediated pathways, we need to be more rigorous in assessing and ensuring the performance of the test (or tests) used. Here we provide an overview of the platforms and technologies, including the strengths and limitations of each test, and discuss what steps are needed to generate confidence in their performance for use in clinical practice. |
| Databáze: | OpenAIRE |
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