Physiological activity of copolymers of 5-isopropenyltetrazole with 1-vinylpyrrolidone

Autor:	V. A. Anan'ev, V. A. Kruglova, S. I. Leshchuk, V. B. Kazimirovskaya, V. V. Annenkov, N. M. Boiko, L. T. Moskvitina
Rok vydání:	1995
Předmět:	Pharmacology Hepatitis B virus Chemistry medicine.drug_class medicine.medical_treatment Anticoagulant Heparin medicine.disease_cause Immunoadjuvant Coagulation Biochemistry Antigen Drug Discovery medicine Copolymer Adjuvant medicine.drug
Zdroj:	Pharmaceutical Chemistry Journal. 29:42-44
ISSN:	1573-9031 0091-150X
Popis:	The physiological activity of the N-H acid 5-isopropenyltetrazole — 1-vinylpyrrolidone copolymers was studied. The copolymers were found to have anticoagulant properties, but unlike heparin, they act only on the initial stages of blood coagulation. The copolymers were discovered to have immunostimulating activity after immunization of mice with sheep erythrocytes. Investigation of the immunoadjuvant properties of the given compounds with respect to the surface antigen of the hepatitis B virus showed them to have an activity at the level of Freund's adjuvant.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::872752aaf78194a770b6a21d2e3c71ff https://doi.org/10.1007/bf02219462 Zobrazit plný text záznamu Full text from SpringerLink