Synthesis of β-phenyl-ethylamine derivatives II condensation of phenols with amino-acetonitriles

Autor:	H. Niewind, P. J. A. van Draanen, M. Asscher, H. D. Moed
Rok vydání:	2010
Předmět:	chemistry.chemical_compound Acetonitriles chemistry Condensation Phenol Organic chemistry Reactivity (chemistry) General Chemistry Phenols Ethylamine Benzene Sympathomimetic Activity
Zdroj:	Recueil des Travaux Chimiques des Pays-Bas. 71:933-944
ISSN:	0165-0513
DOI:	10.1002/recl.19520710911
Popis:	A description is given of the condensation of amino-acetonitriles with phenols according to the method of Houben-Hoesch. The condensations have led to the preparation of a number of compounds of the type: A number of s-amino-acetophenones have been converted into compounds with sympathomimetic activity. An investigation has been made into the conditions and the mechanism of the synthesis, and the influence of substituents in the benzene nucleus on the reactivity of the phenol component. A discussion is devoted to the electronic interpretation of the synthesis according to Houben-Hoesch.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::87252054c5e07ba959db9cefdb3b90cc https://doi.org/10.1002/recl.19520710911 Zobrazit plný text záznamu