| Popis: |
Two new monoclonal antibodies to myelin basic protein (BP) have been prepared. In contrast to the first reported (11), which is an IgG 1 directed against residues 130-137 of certain species, both of the new ones are IgM. One is directed against the region including Phe-Phe residues 90-91, a region which is relatively invariant among many species. The other is relatively species-restricted and probably directed against the guinea pig equivalent of residues 130-137. These antibodies should become useful reagents not only in preparing specific peptide fragments of BP but also in defining some of the elements in the catabolism of myelin in multiple sclerosis (MS), experimental allergic encephalomyelitis (EAE) and other diseases of the central nervous system. |
