Mutation and Expression Analysis of Corticotropin-Releasing Factor 1 Receptor in Adrenocorticotropin-Secreting Pituitary Adenomas1
| Autor: | E.D Gundelfinger, Hendrik Lehnert, D.K Lüdecke, K.D Dieterich |
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| Rok vydání: | 1998 |
| Předmět: |
Pituitary gland
Messenger RNA medicine.medical_specialty Mutation Adenoma Endocrinology Diabetes and Metabolism Biochemistry (medical) Clinical Biochemistry Peptide hormone Biology medicine.disease_cause medicine.disease Biochemistry Cushing syndrome Endocrinology medicine.anatomical_structure Internal medicine Gene expression medicine Receptor |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 83:3327-3331 |
| ISSN: | 1945-7197 0021-972X |
| Popis: | The present study was designed to investigate a possible role of CRF1 receptors (CRF1-R) in the pathogenesis of Cushing’s disease. ACTH-secreting pituitary adenomas and nonsecreting pituitary adenomas have been analyzed for mutations in the CRF1-R gene by PCR and sequencing and been compared with the sequences of normal anterior pituitaries. No mutations affecting the CRF1-R protein have been found in all tumors analyzed. However, we found a significant overexpression of the CRF1-R messenger RNA in ACTH-secreting pituitary adenomas vs. inactive adenomas and normal pituitaries. We conclude that mutations of the CRF1-R are unlikely to be involved in Cushing’s disease. We suggest that the overexpression of the CRF1-R messenger RNA may be related to a disturbed receptor regulation in ACTH-secreting pituitary adenomas. |
| Databáze: | OpenAIRE |
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