Diagnostic Performance of Fecal Immunochemical Test and Sigmoidoscopy for Advanced Right-Sided Colorectal Neoplasms

Autor: Jose Antonio Hermo, Carmen González-Mao, Santiago Soto, Felipe Iglesias, Alfonso Martínez, Joaquín Cubiella, Luis Bujanda, Mikel Larzabal, Vicent Hernandez, Ramiro Macenlle, Pablo Vega, Inés Gil, Luisa De-Castro, Concepción Rivera, Pamela Estévez, Inés Castro, Estela Cid, Antoni Castells, Lucía Cid
Rok vydání: 2014
Předmět:
Zdroj: Digestive Diseases and Sciences. 60:1424-1432
ISSN: 1573-2568
0163-2116
Popis: Colorectal cancer screening effect on right-sided colorectal neoplasia is limited. We compared fecal immunochemical test and simulated sigmoidoscopy diagnostic accuracy for advanced right-sided neoplasia detection. We analyzed 1,292 individuals with complete screening colonoscopy with a fecal immunochemical test determination before colonoscopy. Sigmoidoscopy and “hybrid strategy” (sigmoidoscopy or fecal hemoglobin concentration ≥20 µg hemoglobin/g) diagnostic yield were simulated according to UK Flexible Sigmoidoscopy, Screening for COlon REctum (SCORE), and Norwegian Colorectal Cancer Prevention (NORCCAP) trials criteria to complete colonic examination. We compared sensitivity and specificity of both strategies and of “hybrid strategy” for advanced right-sided neoplasia with McNemar test. An advanced right-sided neoplasia was detected in 47 (3.6 %) subjects. A fecal hemoglobin concentration ≥20 µg hemoglobin/g was determined in 6.6 % of the subjects and 10.1, 12.7, and 23.5 % met UK, SCORE, and NORCCAP criteria, respectively. Fecal immunochemical test was statistically more specific than sigmoidoscopy strategies (93.8 %, UK 90.3 %, SCORE 87.7 %, NORCCAP 77.8 %; p
Databáze: OpenAIRE
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