Exosomes derived from human dental pulp stem cells increase flap survival with ischemia-reperfusion injuries

Autor:	Xin Shi, Guang Yang, Ming-yue Liu, Meng-tong Yuan, Dong Wang, Xiao-feng Wang
Rok vydání:	2023
Předmět:	Embryology Biomedical Engineering
Zdroj:	Regenerative Medicine. 18:313-327
ISSN:	1746-076X 1746-0751
DOI:	10.2217/rme-2022-0206
Popis:	Aim: To investigate the effect of hDPSC-Exos in flap I/R injury, a condition in which tissue damage increases after blood flow is restored to the flap after ischemia. Materials & methods: HUVECs were used to investigate the influences and mechanisms of hDPSC-Exos on cell proliferation and migration. A rat model was established to verify the role of hDPSC-Exos in flap I/R injuries in vivo. Results: hDPSC-Exos promoted the proliferation, migration and tube formation of HUVECs in a dose-dependent way by activating PI3K/AKT signaling pathway, and improved the survival and microvessel density of the flap and suppressed epithelial cell apoptosis. Conclusion: hDPSC-Exos can enhance flap repair after I/R injury. This process may be mediated by the activation of PI3K/AKT signaling pathway.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::870f1fa732ef35b462c75ebbc1c8b8fd https://doi.org/10.2217/rme-2022-0206 Zobrazit plný text záznamu