Assessing mNIS+7 Ionis and international neurologists' proficiency in a familial amyloidotic polyneuropathy trial
| Autor: | Karen A. Lodermeier, Thomas H. Brannagan, Joao Vasco Ferreira, Steven G. Hughes, Violaine Planté-Bordeneuve, Rickey E. Carter, Jessica Robinson-Papp, Rito Bergemann, Peter J. Dyck, Christina Alves, Julie Khoury, John C. Kincaid, John L. Berk, Matilde Laura, Samar S. Ayache, Carol J. Whelan, Brian M. Drachman, Isabel Conceição, Merrill D. Benson, Sami Khella, Michael Polydefkis, Teresa Coelho, Morie A. Gertz, William J. Litchy, Hayet Salhi, Vinay Chaudhry, Stephen B. Heitner, David H. Adams, Giampaolo Merlini, Andrea Cortese, Janice F. Wiesman, P. James B. Dyck, Namita Goyal, Márcio Cardoso, Christopher J. Klein, Katherine Ruzhansky, Annabel K. Wang, Michelle L. Mauermann, Marcus V. Pinto, Márcia Waddington-Cruz, Jenny L. Davies, Céline Labeyrie, Peter D. Gorevic, Elizabeth J. Ackermann |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Physiology business.industry Neurologic Signs medicine.disease 03 medical and health sciences Cellular and Molecular Neuroscience 030104 developmental biology 0302 clinical medicine Peripheral neuropathy Muscle nerve Physiology (medical) Sensation Severity of illness medicine Physical therapy Neurology (clinical) Abnormality business Polyneuropathy 030217 neurology & neurosurgery Cohort study |
| Zdroj: | Muscle & Nerve. 56:901-911 |
| ISSN: | 1097-4598 0148-639X |
| Popis: | Introduction Polyneuropathy signs (Neuropathy Impairment Score, NIS), neurophysiologic tests (m+7Ionis ), disability, and health scores were assessed in baseline evaluations of 100 patients entered into an oligonucleotide familial amyloidotic polyneuropathy (FAP) trial. Methods We assessed: (1) Proficiency of grading neurologic signs and correlation with neurophysiologic tests, and (2) clinometric performance of modified NIS+7 neurophysiologic tests (mNIS+7Ionis ) and its subscores and correlation with disability and health scores. Results The mNIS+7Ionis sensitively detected, characterized, and broadly scaled diverse polyneuropathy impairments. Polyneuropathy signs (NIS and subscores) correlated with neurophysiology tests, disability, and health scores. Smart Somatotopic Quantitative Sensation Testing of heat as pain 5 provided a needed measure of small fiber involvement not adequately assessed by other tests. Conclusions Specially trained neurologists accurately assessed neuropathy signs as compared to referenced neurophysiologic tests. The score, mNIS+7Ionis , broadly detected, characterized, and scaled polyneuropathy abnormality in FAP, which correlated with disability and health scores. Muscle Nerve 56: 901-911, 2017. |
| Databáze: | OpenAIRE |
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