Preparative Chromatography Technique in the Removal of Isostructural Genotoxic Impurity in Rizatriptan: Use of Physicochemical Descriptors of Solute and Adsorbent

Autor:	Apurba Bhattacharya, Sandeep Kale, P. K. Dubey, Abijar Joyebbhai Bhori, Arvind M. Lali, Manoj Ramesh Kharkar, Srinivasula Reddy Maddula, Rakeshwar Bandichhor, Kushal Surajmal Manudhane, K. R. Janardana Sarma
Rok vydání:	2009
Předmět:	Chromatography Dimer Organic Chemistry Rizatriptan Partition coefficient Hydrophobic effect Dissociation constant chemistry.chemical_compound Adsorption chemistry Impurity medicine Physical and Theoretical Chemistry Isostructural medicine.drug
Zdroj:	Organic Process Research & Development. 13:683-689
ISSN:	1520-586X 1083-6160
Popis:	The development of preparative negative hydrophobic interaction chromatographic technique based on molecular structural descriptors and physicochemical descriptors e.g. the dissociation constant (pKa), partition coefficient (logP), and distribution coefficient (logD) for removal of a structurally related genotoxic dimer impurity from rizatriptan bulk drug is presented.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8704fb32c6da13bb51395f6e78d28696 https://doi.org/10.1021/op9000093 Zobrazit plný text záznamu