Biochemical and ultrastructural changes in livers of cadmium-treated rats*1
| Autor: | Robert Bruce, Leon C. King, Bruce A. Fowler, Suzanne Q. Chaney, Thomas A. Hinners, Edward J. Faeder |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Pharmacology
Cadmium Kidney medicine.medical_specialty Endoplasmic reticulum Carbonic anhydrase activity chemistry.chemical_element Ornithine Biology Toxicology chemistry.chemical_compound Red blood cell medicine.anatomical_structure Endocrinology chemistry Internal medicine Liver tissue Ultrastructure medicine |
| Zdroj: | Toxicology and Applied Pharmacology. 39:473-487 |
| ISSN: | 0041-008X |
| DOI: | 10.1016/0041-008x(77)90139-9 |
| Popis: | Groups of male Wistar rats were given 0, 0.25, 0.50, or 0.75 mg of Cd/kg body wt sc 3 days/week for 8 weeks. At the times sampled, the fraction of total cadmium administered in the liver and kidney (40–50% in the liver and 6% in the kidney) remained constant. Until Week 6, no differences were found in plasma aspartate aminotransferase (AAT), γ-glytamyl transpeptidase (GT), and ornithine carbamoyl transferase (OCT) activities. At Week 6, GT and AAT activities became elevated. Small but significant changes in red blood cell carbonic anhydrase activity occurred at 6 and 8 weeks. Electron microscopic examination of liver tissue indicated dilatation of the rough endoplasmic reticulum and prolification of prominent connective tissue fiber bundles at Week 6. These results show a correlation between ultrastructural liver changes and elevations in plasma enzyme activities, which are usually considered to be indicative of chronic liver damage. |
| Databáze: | OpenAIRE |
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