113-POS

Autor: Aida Kasaei Roodsari, Sonia Kajla, Catherine Michel, Julie L. Lavoie, Dominique S. Genest, Jolanta Gutkowska, Stéphanie Falcao
Rok vydání: 2015
Předmět:
Zdroj: Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health. 5:61
ISSN: 2210-7789
DOI: 10.1016/j.preghy.2014.10.119
Popis: Objectives Gestational hypertensive disorders affect 6–8% of all pregnancies and are the leading cause of maternal mortality in industrialized countries, accounting for 16% of all deaths. Women with hypertension have an increased risk (15–25%) of developing preeclampsia. Our aim was to investigate the role of the angiotensin-(1–7) axis in preeclampsia superimposed on chronic hypertension. Methods We used female mice overexpressing human angiotensinogen and renin (R+A+) as a model of preeclampsia superimposed on chronic hypertension. As we have shown that exercise improves preeclampsia features in this model, to assess the functional role of the different parameters studied, we trained mice by placing them in cages with access to an exercise wheel prior to and throughout pregnancy. At the end of gestation, mice were sacrificed. Blood pressure was measured by telemetry. Results We found that the renal Mas receptor was decreased in pregnant sedentary transgenic mice compared to controls whereas this was significantly increased with exercise training. We found increased renal angiotensin-converting enzyme type 2 in trained transgenic mice compared with sedentary mice. Put together, this may not only increase the production of angiotensin-(1–7) but it may amplify its effects which would counter angiotensin II negative effects in the kidney. Supporting a functional contribution of this modulation, we found that pathological features observed in sedentary transgenic mice were prevented in trained mice such as increased blood pressure and proteinuria. Conclusions This study demonstrates that modulation of the angiotensin-(1–7) axis seems to be a key mechanism in the development of preeclampsia superimposed on chronic hypertension, which can be improved by exercise training to prevent disease features in an animal model. Disclosures A. Kasaei Roodsari: None. D.S. Genest: None. S. Falcao: None. C. Michel: None. S. Kajla: None. J. Gutkowska: None. J.L. Lavoie: None.
Databáze: OpenAIRE
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