Malignant brenner tumor of the ovary: Electron microscopic study of a case responsive to radiation and chemotherapy
| Autor: | David N. Danforth, Thomas A. Victor, Max Haid, C. Michael Weldon-Linne |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Cancer Research
Chemotherapy Pathology medicine.medical_specialty Cyclophosphamide business.industry medicine.medical_treatment Ovary Malignant Brenner tumor Coelomic epithelium Amethopterin medicine.anatomical_structure Oncology Metaplasia medicine Doxorubicin medicine.symptom business medicine.drug |
| Zdroj: | Cancer. 51:498-508 |
| ISSN: | 1097-0142 0008-543X |
| DOI: | 10.1002/1097-0142(19830201)51:3<498::aid-cncr2820510323>3.0.co;2-b |
| Popis: | A patient with malignant Brenner tumor of the ovary is presented. The tumor responded to combined therapy with radiation plus doxorubicin + cyclophosphamide despite earlier failure on a single alkylating agent (levophenylalanine mustard). The patient next exhibited a brief response to chemotherapy with hexamethylmelamine + cyclophosphamide + amethopterin + 5-fluorouracil. The histologic findings and ultrastructure of the tumor are discussed in detail. The morphologic features are consistent with the proposed origin of Brenner tumors from coelomic epithelium through a process of secondary urothelial metaplasia. |
| Databáze: | OpenAIRE |
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