In vivo optical clearing of human skin under the effect of aqueous solutions of some monosaccharides

Autor:	V. V. Nechaev, Valery V. Tuchin, I. T. Shagautdinova, K. V. Berezin, M. L. Chernavina, A. M. Likhter, E. M. Antonova, K. N. Dvoretsky
Rok vydání:	2019
Předmět:	chemistry.chemical_classification History Aqueous solution Molecular model Chemistry Triatomic molecule Human skin Computer Science Applications Education Molecular dynamics chemistry.chemical_compound In vivo Biophysics Glycerol Monosaccharide sense organs
Zdroj:	Journal of Physics: Conference Series. 1400:033018
ISSN:	1742-6596 1742-6588
DOI:	10.1088/1742-6596/1400/3/033018
Popis:	The results of in vivo optical immersion clearing of human skin under the effect of aqueous solutions of some immersion agents (monosaccharides of ribose, glucose and fructose, as well as glycerol, a triatomic alcohol) were obtained with the use of the OCT method. Values of average velocity of scattering coefficient change, obtained through an averaged A-scan of the OCT signal in the region of derma with the depth of 350 to 700 µm, were determined to evaluate the optical clearing efficiency. The velocity of scattering coefficient change and the optical clearing potential value appeared to be well correlated. The complex molecular modeling of a number of immersion clearing agents with a mimetic peptide of collagen (GPH)3, carried out with the use of the methods of classical molecular dynamics and quantum chemistry, allowed to identify correlations between the optical clearing efficiency and the energy of intermolecular interaction of clearing agents with a collagen peptide fragment.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::86e82ad9814b78692f84fa35c90b9aea https://doi.org/10.1088/1742-6596/1400/3/033018 Zobrazit plný text záznamu