| Autor: |
Manon Belhoste, Gilles Allenbach, Thomas Agius, Raphael P. H. Meier, Jean-Pierre Venetz, Jean-Marc Corpataux, Antoine Schneider, Déla Golshayan, John O. Prior, Sébastien Déglise, Marie Nicod-Lalonde, Alban Longchamp |
| Rok vydání: |
2022 |
| Zdroj: |
Frontiers in Transplantation. 1 |
| ISSN: |
2813-2440 |
| DOI: |
10.3389/frtra.2022.1065415 |
| Popis: |
BackgroundThere is no consensus on how to predict post-transplant function of donation after circulatory death (DCD) kidneys. Thus, we aimed to identify renal scintigraphy parameters that could predict 1-year kidney function.MethodsIn this single center study, we included all consecutive DCD kidney recipients between 2013 and 2021 (n = 29). Patients who did not have a scintigraphy within 10 days of transplantation (n = 3), recipients of multiple organs and less than 18 years old were excluded (n = 1). Primary endpoint was the estimated glomerular filtration rate (eGFR).ResultsMedian eGFR and serum creatinine at 1 year were 67 µmol/L (56–81) and 111 ml/min (99–132), respectively. Among parameters tested, the 3rd/2nd-minute activity ratio had the best diagnostic performance (AUC: 0.74 and 0.71, for eGFR and creatinine) 1 year post transplantation. Using 1.21 as the best cut off, the 3rd/2nd-minute activity ratio specificity and sensitivity to predict eGFR >60 ml/min was 0.82 and 0.83. Renal function was significantly better at 1 week, 3, 6, and 12 months after transplantation in patients with 3rd/2nd-minute activity ratios above 1.21.ConclusionThis study suggests that the 3rd/2nd-minute activity ratio can predict graft function at 1 year. The benefit of post-transplant scintigraphy should be further validated in a prospective cohort. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
