Complement Activation in Dialysis: Effects on Cytokines, Lymphocyte Activation and β2 Microglobulin
| Autor: | M. Gardinali, A. Calcagno, L. Conciato, A. Agostoni, A. Rosti, P. Cori, N. Vozzo, A. Moroni, A. Anelli, U. Zoni, M. Del Prete |
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| Rok vydání: | 1994 |
| Předmět: |
Interleukin 2
medicine.medical_specialty Chemistry Beta-2 microglobulin medicine.medical_treatment 030232 urology & nephrology Biomedical Engineering Medicine (miscellaneous) Bioengineering General Medicine 030204 cardiovascular system & hematology Complement system Biomaterials 03 medical and health sciences 0302 clinical medicine Membrane Endocrinology Cytokine Internal medicine Immunology medicine Anaphylatoxin Tumor necrosis factor alpha Receptor medicine.drug |
| Zdroj: | The International Journal of Artificial Organs. 17:337-344 |
| ISSN: | 1724-6040 0391-3988 |
| Popis: | Anaphylatoxins generated by complement activation by filter membranes are present in plasma during hemodialysis (HD). In the presence of endotoxins which may contaminate the dialysate, they can trigger monocytes to produce interleukin-1 (IL-1) and tumor necrosis factor (TNF), with detrimental effects for the patients. We have investigated whether or not the use of complement activating (cuprophan) and non- (or less-) activating membranes (polysulfone, polymethylmethacrylate or polyacrylonitrile) per se influences cytokine levels in HD patients. Our results indicate that if a sterile bicarbonate solution is used as dialysate, there are no significant increases in IL-1, TNF, interleukin-2 (IL-2) and soluble IL-2 receptors (sIL-2r) throughout HD, even with cuprophan membranes. Moreover even a prolonged use of this membrane (three months) did not change pre-dialysis levels of cytokines and receptors. Use of complement activating membranes also does not influence β2 microglobulin levels. |
| Databáze: | OpenAIRE |
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