Th17 cells confer long-term adaptive immunity to oropharyngeal candidiasis (P3308)
| Autor: | Nydiaris Hernandez-Santos, Anna Huppler, Alanna Peterson, Shabaana Khader, Kyle McKenna, Sarah Gaffen |
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| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 190:134.7-134.7 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.190.supp.134.7 |
| Popis: | Oropharyngeal candidiasis (OPC) is an opportunistic infection of the oral cavity caused primarily by Candida albicans. OPC particularly afflicts HIV+ patients with low CD4 counts, suggesting a role for CD4+ T cells in host defense. Experimental models of OPC have strongly suggested that immunity to OPC is IL-17-dependent, and humans with rare genetic defects that result in Th17 deficiency are associated with the development of OPC. However, other sources of IL-17 have been described, particularly in the innate compartment, but the relative contribution of adaptive and innate sources of IL-17 during OPC has not been well articulated. Here, we showed that development of adaptive immune responses in OPC results in a ~1 log decrease in fungal burden, tightly associated with an increased frequency of antigen-specific CD4+IL-17+ (Th17) cells. Importantly, adoptive transfer of Candida-primed Th17 cells into Rag1-/- mice resulted in protection from disease. Surprisingly, however, CD4-/- mice were resistant to OPC, which was linked, at least in part, with compensatory IL-17 production by both CD8+ and double-negative (DN) T cells. The adoptive transfer of CD8+IL-17+ or DN cells into Rag1-/- mice resulted in protection from OPC. Therefore, Th17 cells contribute to C. albicans clearance but their absence can be compensated by alternative sources of IL-17. These findings implicate CD8+IL-17+ and DN cells as vaccine targets in immunocompromised populations. |
| Databáze: | OpenAIRE |
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