Enterohepatic Circulation of Fenofibrate Metabolites in the Rat, a Peroxisome Proliferator Responsive Species
| Autor: | John Caldwell, G. F. Blane, J.-P. Guichard, A. Weil |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Drug
medicine.medical_specialty Fenofibrate Clofibrate biology Cholesterol medicine.drug_class media_common.quotation_subject Context (language use) Fibrate chemistry.chemical_compound Endocrinology chemistry Internal medicine medicine biology.protein Enzyme inducer Enterohepatic circulation medicine.drug media_common |
| Zdroj: | Archives of Toxicology ISBN: 9783540185123 |
| Popis: | Fenofibrate {2-[4-(4-chlorobenzoyl)-phenoxy]-2-methylpropanoic acid-1 -methyl-ethyl ester; trade name: Lipanthyl} is a hypolipidaemic drug structurally related to Clofibrate and other fibrate-type lipid-lowering agents. Fenofibrate is more potent than Clofibrate in reducing plasma triglycerides and cholesterol concentrations (Daubresse 1980; Brown et al. 1986). In recent years, there has been considerable interest in the safety of fibrate hypolipidaemics, particularly since they are enzyme inducers and peroxisome proliferators in rodent liver (Cohen and Grasso 1981; Reddy et al. 1987). The toxicological significance of this phenomenon, particularly its relevance in risk assessment, is uncertain. The biliary disposition of the hypolipidaemic drug fenofibrate has been examined in rat, in the context of furthering its safety evaluation. |
| Databáze: | OpenAIRE |
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