Absence of Cardiac Toxicity of Zidovudine in Infants

Autor:	Douglas S. Moodie, E. John Orav, Samuel Kaplan, George Sopko, Steven E. Lipshultz, Wyman W. Lai, Kirk A. Easley, Steven D. Colan, Thomas J. Starc, J. Timothy Bricker, Kenneth McIntosh
Rok vydání:	2000
Předmět:	medicine.medical_specialty Pediatrics Pregnancy Heart disease biology Perinatal Exposure business.industry General Medicine Prenatal care medicine.disease biology.organism_classification Surgery Zidovudine Acquired immunodeficiency syndrome (AIDS) medicine Risk factor Sida business medicine.drug
Zdroj:	New England Journal of Medicine. 343:759-766
ISSN:	1533-4406 0028-4793
Popis:	Background Some evidence suggests that perinatal exposure to zidovudine may cause cardiac abnormalities in infants. We prospectively studied left ventricular structure and function in infants born to mothers infected with the human immunodeficiency virus (HIV) in order to determine whether there was evidence of zidovudine cardiac toxicity after perinatal exposure. Methods We followed a group of infants born to HIV-infected women from birth to five years of age with echocardiographic studies every four to six months. Serial echocardiograms were obtained for 382 infants without HIV infection (36 with zidovudine exposure) and 58 HIV-infected infants (12 with zidovudine exposure). Repeated-measures analysis was used to examine four measures of left ventricular structure and function during the first 14 months of life in relation to zidovudine exposure. Results Zidovudine exposure was not associated with significant abnormalities in mean left ventricular fractional shortening, end-diastolic dimension, contract...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::86c767e53a9eafc3f004c46975bf614c https://doi.org/10.1056/nejm200009143431102 Zobrazit plný text záznamu