Discovery, chemistry, and chemical biology of microbial products

Autor:	Kazuro Shiomi, Satoshi Ōmura
Rok vydání:	2007
Předmět:	chemistry.chemical_classification biology General Chemical Engineering Microorganism Chemical biology General Chemistry biology.organism_classification Cyclic peptide Enzyme chemistry Biochemistry Chitinase biology.protein Atpenin A5 Volume concentration Haemonchus contortus
Zdroj:	Pure and Applied Chemistry. 79:581-591
ISSN:	1365-3075 0033-4545
DOI:	10.1351/pac200779040581
Popis:	Our long-standing and continual screening of microorganisms, especially for antiparasitic agents, has produced a wide variety of compounds of global importance, such as the avermectins. Recent discoveries include nafuredin, atpenins, argifin, and argadin. Nafuredin is a helminth-specific inhibitor of electron-transport enzyme, complex I, which exhibits anthelmintic activity against Haemonchus contortus in sheep. The atpenins are the most potent complex II inhibitors ever reported. Co-crystallization study of atpenin A5 and E. coli complex II indicated the binding mechanism of ubiquinone to complex II. Argifin and argadin are the first cyclic peptides to inhibit chitinase at low concentration. Though structurally similar, their chitinase inhibition mechanisms are quite different.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::86bf1fe773554649ec8a5c26bd178f5f https://doi.org/10.1351/pac200779040581 Zobrazit plný text záznamu