Hepatic infiltration helps predict outcome in dogs with multicentric large B cell lymphoma

Autor: T. Denoeux, Frédérique Ponce, Gabriel Chamel, P. Denoeux, David Sayag
Rok vydání: 2019
Předmět:
Zdroj: Revue Vétérinaire Clinique. 54:79-86
ISSN: 2214-5672
Popis: Summary Background The five-level WHO staging system is currently the standard for canine lymphomas. In humans, staging for Non-Hodgkin lymphomas has recently evolved to the Lugano classification. In this four-level classification, the splenic infiltration does not induce stage migration from stage III, while hepatic involvement is considered as a more advanced stage together with bone marrow or non-lymphoid organs infiltration. Objective The objective of this pilot study is to evaluate the accuracy of the Lugano staging system, compared to the WHO, in predicting first remission duration (FRD) in dogs. Material and methods Thirty dogs with multicentric large B cell lymphoma, staged according to both systems, and treated with a standard chemotherapy protocol were retrospectively included. Kaplan-Meier curves were established for all stages and compared using a Log Rank test. Results The median FRD was 157 days. Factors significantly associated with shorter FRD in the univariate analysis were substage b (P = 0.024), WHO stage V (P = 0.008) and Lugano stage IV (P = 0.002). Two multivariate Cox models were then compared: the model including substage together with both WHO and Lugano staging was statistically superior to predict FRD as compared to the model including only substage and WHO staging (P = 0.014). Conclusion Taking hepatic involvement into account allows better risk stratification for canine LBCL.
Databáze: OpenAIRE
Externí odkaz: