| Popis: |
Background Despite continuous improvement, tumor, nodes, and metastases (TNM) staging has been deficient in prognosticating in patients suffering from non-small cell lung cancer (NSCLC). To supplement TNM staging, this systematic review and meta-analysis aimed to evaluate the prognostic value of the regulatory T cells (Treg). Methods A keyword search was conducted in the MEDLINE database through PubMed for full-text original human studies from any region published in English during the last 10 years. Eligible for inclusion were studies evaluating the prognostic value of the number of Treg cells and pre-specified biomarkers in NSCLC. Case studies, case series, systematic reviews, and meta-analyses were excluded. Two reviewers independently screened the studies and assessed risk-of-bias using the Quality in Prognosis Studies (QUIPS) tool. One reviewer used an automation tool for screening, which was also used to facilitate data extraction. Meta-analysis was done for studies reporting significant multivariate hazards ratio (HR). Results Out of 258 retrievals, 19 studies were included in the final review. The low number of Treg cells was found significantly associated with improved overall survival (pooled log OR: 1.626; 95% CI: 1.324, 1.928; p (2-tailed) |
