| Autor: |
Luis Geffner, Juan José Paganini, Federico Benetti, Roberto Paganini, Agustin Fronzutti, Amit N. Patel, Daniel Brusich |
| Rok vydání: |
2008 |
| Předmět: |
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| Zdroj: |
Stem Cell Research and Therapeutics ISBN: 9781402085017 |
| DOI: |
10.1007/978-1-4020-8502-4_12 |
| Popis: |
Congestive heart failure (CHF) is a complex clinical syndrome resulting from myocardial dysfunction that impairs the cardiovascular system’s function. Both medical and surgical therapy still results in a large number of patients with very few options and persistent ventricular dysfunction. The major process to reverse ventricular remodeling would be the enhancement of regeneration of cardiac myocytes, as well as the stimulation of neovascularization within the affected area of the myocardium. This can be achieved by introducing progenitor cells that are capable of differentiating into cardiac myocytes or that promote neovascularization and restore the normal characteristics of myocardium environment. However a number of issues remain as to the type of cells, delivery, timing, and mechanisms involved. There have been a number of clinical trials based on very early small and large animal experiments that investigate stem cell therapy for heart failure, most of which have employed bone marrow stem cells or myoblasts. The majority of studies demonstrate an improvement in ventricular function, reduction in scar, or improvement in symptoms. There are a few trials that show no improvement at all. Here we present our surgical experience over the past 4 years with autologous and fetal liver stem cells in patients with heart failure. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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