Preparation and characterization of polymer nanocomposites coated magnetic nanoparticles for drug delivery applications
| Autor: | Vairamuthu Raj, G. Prabha |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Materials science
Polymer nanocomposite Scanning electron microscope technology industry and agriculture Nanoparticle Nanotechnology macromolecular substances 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences 0104 chemical sciences Electronic Optical and Magnetic Materials Chitosan chemistry.chemical_compound chemistry Drug delivery Zeta potential Magnetic nanoparticles Fourier transform infrared spectroscopy 0210 nano-technology Nuclear chemistry |
| Zdroj: | Journal of Magnetism and Magnetic Materials. 408:26-34 |
| ISSN: | 0304-8853 |
| DOI: | 10.1016/j.jmmm.2016.01.070 |
| Popis: | In the present research work, the anticancer drug ‘curcumin’ is loaded with Chitosan (CS)-polyethylene glycol (PEG)-polyvinylpyrrolidone (PVP) (CS-PEG-PVP) polymer nanocomposites coated with superparamagnetic iron oxide (Fe3O4) nanoparticles. The system can be used for targeted and controlled drug delivery of anticancer drugs with reduced side effects and greater efficiency. The prepared nanoparticles were characterized by Fourier transmission infrared spectroscopy (FTIR), vibrating sample magnetometry (VSM), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Curcumin drug loaded Fe3O4-CS, Fe3O4-CS-PEG and Fe3O4-CS-PEG-PVP nanoparticles exhibited the mean particle size in the range of 183–390 nm with a zeta potential value of 26–41 mV as measured using Malvern Zetasizer. The encapsulation efficiency, loading capacity and in-vitro drug release behavior of curcumin drug loaded Fe3O4-CS, Fe3O4-CS-PEG and Fe3O4-CS-PEG-PVP nanoparticles were studied using UV spectrophotometer. Besides, the cytotoxicity of the prepared nanoparticles using MTT assay was also studied. The curcumin drug release was examined at different pH medium and it was proved that the drug release depends upon the pH medium in addition to the nature of matrix. |
| Databáze: | OpenAIRE |
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