Synthesis and in vitro evaluation of zerumbone pendant derivatives: potent candidates for anti-diabetic and anti-proliferative activities
| Autor: | Kokkuvayil Vasu Radhakrishnan, P. Nisha, P. Sharathna, I. G. Shibi, Jayaram Saranya, T. R. Reshmitha, B. P. Dhanya, Greeshma Gopalan |
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| Rok vydání: | 2017 |
| Předmět: |
biology
010405 organic chemistry Chemistry Stereochemistry General Chemistry Pharmacology Anti proliferative biology.organism_classification 01 natural sciences Catalysis In vitro 0104 chemical sciences HeLa 03 medical and health sciences 0302 clinical medicine Cell culture Glycation 030220 oncology & carcinogenesis Materials Chemistry Cytotoxic T cell HT1080 Cancer cell lines |
| Zdroj: | New Journal of Chemistry. 41:6960-6964 |
| ISSN: | 1369-9261 1144-0546 |
| DOI: | 10.1039/c7nj01098b |
| Popis: | A series of zerumbone pendant derivatives were synthesized and evaluated for their α-glucosidase, α-amylase and glycation inhibition activities. In our study, some of the derivatives showed potent inhibitory activity in micromolar concentration. In addition, investigations were carried out to screen the cytotoxic effects of some selected derivatives against various cancer cell lines viz., A549, HCT116, HeLa, HT1080 and MDAMB231. Two of the derivatives showed potent activity towards HCT116 and HeLa cell lines. |
| Databáze: | OpenAIRE |
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