The Patterns of Interferon-Gamma and Interleukin-10 Production as a Potential Immunological Biomarker for the Outcome of Mycobacterium Tuberculosis Infection
| Autor: | Friday Alfred Ehiaghe, Anthony Chukwuka Nwaobi, Emmanuel Babatunde Adedeji, Benson Olu Akinshipe, Herbert Obi Okpala |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Immunodiagnostics Tuberculosis biology Latent tuberculosis business.industry biology.organism_classification medicine.disease Mycobacterium tuberculosis 03 medical and health sciences 030104 developmental biology Concomitant Immunology Medicine Biomarker (medicine) Interferon gamma Immunocompetence business medicine.drug |
| Zdroj: | International Journal of Immunology. 5:97 |
| ISSN: | 2329-177X |
| DOI: | 10.11648/j.iji.20170506.12 |
| Popis: | Deficiencies in current tuberculosis (TB) immunodiagnostics pipeline demand new approaches to control TB. Because the balance in key pro- and anti-inflammatory cytokines production could determine Mycobacterium Tuberculosis (MTb) infection outcome, this study aimed to determine the patterns of MTb-specific antigen-stimulated Interferon-gamma (IFN-y) and Interleukin-10 (IL-10) production in different clinical forms of MTb infection and to evaluate their concomitant changes during anti-TB treatment (ATT). Overall, 84 BCG-vaccinated HIV-negative adults, consisting of 25 Healthy Community Controls (HCC), 27 Latent Tuberculosis Infection (LTBI) cases, and a cohort of 32 Acute Pulmonary Tuberculosis (APTB) patients were investigated for IFN-y and IL-10 responses at enrollment (base-line) and during ATT at 2-month (ATT1) and 6-month (ATT2). At enrollment, groups didn’t differ significantly in age, gender, or CD4+ T counts but differed in the other socio-demographics, and hematological parameters, p |
| Databáze: | OpenAIRE |
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