Synthesis ofα-Aminophosphonic Octapeptide, Phe–Gly–Ser–Leu–AlaP–Phl–Leu–Pro, an Analog with Partial Sequence oferbB-2 Gene Product

Autor:	Tadashi Teshima, Kaoru Inami, Hideaki Miyashita, Tetsuo Shiba
Rok vydání:	1995
Předmět:	Gene product chemistry.chemical_classification chemistry Stereochemistry Peptide bond Sequence (biology) Peptide General Chemistry Gene Chemical synthesis Coupling reaction Amino acid
Zdroj:	Bulletin of the Chemical Society of Japan. 68:942-949
ISSN:	1348-0634 0009-2673
Popis:	A chemical synthesis was performed of an octapeptide with a phosphonic ester linkage, which corresponds to a variation of the partial sequence of a gene product of erb B-2. The phosphonic ester linkage was successfully prepared through a coupling reaction of magnesium salt of the hydroxypeptide with phosphonochloridate, without damage of the peptide bond. The free aminophosphonic peptide as the final product gave a single peak on the ODS column, and a reasonable ratio of the component amino acids. The reaction series exploited here might be useful as a general procedure for preparation of the phosphonic peptide.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8684e4530d3eba467cf2d5bace892dc2 https://doi.org/10.1246/bcsj.68.942 Zobrazit plný text záznamu