Effect of N-Acetylcysteine on the Matrix Metalloproteinases and Their Inhibitors in Carbon Tetrachloride-Induced Hepatotoxicity

Autor:	Venugopal P. Menon, Khalid S. Al-Numair, Abdullah H. Al-Assaf, Ali A. Alshatwi, Narasimhanaidu Kamalakkannan
Rok vydání:	2009
Předmět:	Kidney Proteases Nutrition and Dietetics Chemistry Liver and kidney Matrix metalloproteinase Pharmacology medicine.disease Extracellular matrix Acetylcysteine chemistry.chemical_compound medicine.anatomical_structure Biochemistry Fibrosis medicine Carbon tetrachloride Food Science medicine.drug
Zdroj:	Preventive Nutrition and Food Science. 14:14-20
ISSN:	2287-1098
DOI:	10.3746/jfn.2009.14.1.014
Popis:	Matrix metalloproteinases (MMPs) are a group of zinc proteases that serve the function of breaking down extracellular matrix (ECM). The present study evaluated the role of N-acetylcysteine (NAC) on the increased deposition of ECM in hepatic and glomerular fibrosis caused by carbon tetrachloride (CCl₄). The activity of MMPs increased and the levels of tissue inhibitors of metalloproteinases 1 and 2 (TIMP-1 and TIMP-2) decreased in the liver and kidney of CCl₄-treated rats. Rats treated with CCl₄ and NAC showed increased activities of MMPs and decreased levels of TIMP-1 and TIMP-2 in the liver and kidney. Treatment with NAC resulted in the effective degradation of ECM due to an increase in the activities of MMPs and a decrease in the levels of TIMPs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::868129cd5fa57f12af915464c5b8f0be https://doi.org/10.3746/jfn.2009.14.1.014 Zobrazit plný text záznamu