Rapid identification of novel influenza virus genetic variants in surveillance by routine sequencing

Autor:	Olav Hungnes, Grethe H Krogh, Helvi Holm Samdal, Ivar Ørstavik
Rok vydání:	2004
Předmět:	Rapid identification Vaccine strain Genetic variants Outbreak General Medicine Biology Virology H5N1 genetic structure Antigenic drift Virus Virus detection
Zdroj:	International Congress Series. 1263:695-698
ISSN:	0531-5131
Popis:	The rapid antigenic drift of human influenza viruses necessitates annual reevaluation of vaccine composition, and time may be short between the start of the outbreaks and the time when the next season's vaccine strains need to be determined. The application of genetic characterisation shortly after virus detection may accelerate the detection of epidemiological trends like the emergence of novel viruses. Further antigenic characterisation and steps to obtain candidate vaccine strains may then be taken in a more selective and efficient manner. We describe here the early detection of novel influenza B and A(H3N2) genetic variants in the Norwegian influenza surveillance during the 2001/2002 and 2002/2003 seasons.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::867fb5805b6378b66f834f10c33553e5 https://doi.org/10.1016/j.ics.2004.02.094 Zobrazit plný text záznamu Full Text from ScienceDirect